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KMID : 0861020110260040075
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Korea Journal of Herbology
2011 Volume.26 No. 4 p.75 ~ p.81
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The Effects of Magnoliae officinalis Cortex and Machili thunbergii Cortex on Small Intestinal Motility
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Lee Kyung-Jin
Park Geun-Yong
Park Kyu-Ha
Liu Kwang-Hyeon
Kim Tae-Wan
Ham In-Hye
Bu Young-Min
Choi Ho-Young
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Abstract
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Objectives: Magnoliae officinalis Cortex (MOC) has been used in traditional medicine for digestive diseases in
Korea, China and Japan. However, Machili thunbergii Cortex (MTC) also has been used as a substitute of MOC
in Korea sometimes. Thus, this study was carried out to investigate and compare the effects of MOC and MTC
on intestinal motility of isolated small intestinal segments from ICR mouse.
Methods: Changes in motility were recorded via isometric transducers connected to a data acquisition system
and amplitude, frequency and area under the curve (AUC) of intestinal spontaneous phasic contraction were
compared.
Results: The MOC extracts (1∼30μg/mL) dose-dependently decreased both amplitudes and frequencies of the
spontaneous phasic contraction, but not AUC. However, high concentration of MOC (100 μg/mL) evoked tonic
contraction. And it was not inhibited by tetrodotoxin, a sodium channel blocker, and nifedipine, a L-type Ca2+
channel antagonist. These results suggested that MOC (100 μg/mL)-induced tonic contraction is not mediated
by nerve or L-type Ca2+ channel. On the other hand, the MTC extracts dose-dependently inhibited amplitude
and AUC, but not the frequency.
Conclusions: Although both MOC and MTC affected intestinal motility, MOC is more effective on intestinal
motility than MTC. And MOC has been used as a traditional medicine for a long time but not MTC. Thus, we
suggested that MTC should not be used in Korea as a substitute of MOC and MOC might be useful traditional
medicine for gastrointestinal disease. The mechanism of MOC is still remained to elucidate.
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KEYWORD
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Magnoliae officinalis Cortex, Machili thunbergii Cortex, small intestine, intestinal motility
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